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Site last updated October 2019

The HOPE Study

The original Hepatoblastoma Origins & Pediatric Epidemiology (HOPE) Study enrolled 383 children with hepatoblastoma diagnosed during 2000-2010 in the United States.  It remains the largest study of the causes of hepatoblastoma to date.  There have been 7 published reports (listed below) from HOPE on various potential causative factors. 

In addition, DNA samples collected by the HOPE study are forming the basis for the first genome-wide association study of hepatoblastoma. 

 

We are now developing the HOPE Registry and Biobank to allow patients to participate in research on the causes and outcomes of hepatoblastoma on an ongoing basis.  In addition, the HOPE Registry and Biobank will be open to patients anywhere, not just the United States, and will enroll first-degree relatives as well.

 

Please stay tuned for the opening of the HOPE Registry and Biobank.  We anticipate opening by February 2020.

Maternal and paternal occupational exposures and hepatoblastoma: results from the HOPE study through the Children’s Oncology Group (COG)
Neonatal Medical Exposures and Characteristics of Low Birth Weight Hepatoblastoma Cases: A Report From the Children's Oncology Group
Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: A report from the Children’s Oncology Group
Parental tobacco and alcohol use and risk of hepatoblastoma in offspring: A report from the Children’s Oncology Group
Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study
Parental infertility, infertility treatment and hepatoblastoma: a report from the Children's Oncology Group
Congenital Abnormalities and Hepatoblastoma: A Report from the Children’s Oncology Group (COG) and the Utah Population Database (UPDB)