The original Hepatoblastoma Origins & Pediatric Epidemiology (HOPE) Study enrolled 383 children with hepatoblastoma diagnosed during 2000-2010 in the United States.  It remains the largest study of the causes of hepatoblastoma to date.  The published reports listed below explain various potential causative factors. 

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In addition, DNA samples collected by the HOPE study are forming the basis for the first genome-wide association study of hepatoblastoma. 

 

We are now developing the HOPE Registry and Biobank to allow patients to participate in research on the causes and outcomes of hepatoblastoma on an ongoing basis.  In addition, the HOPE Registry and Biobank will be open to patients anywhere, not just the United States, and will enroll first-degree relatives as well.

 

Please stay tuned for the opening of the HOPE Registry and Biobank.  We anticipate opening in 2024.