Dr. O’Neill is a pediatric oncology physician-scientist with an interest in translational research and a growing expertise in the care of pediatric solid tumor patients. She has followed a unique path, focused initially on the use of imaging to enhance diagnostics and therapeutics in pediatric solid tumor patients, now with an increasing interest in the Ewing sarcoma cell surfaceome and immune environment. Her prior work generating a targeted imaging probe to more sensitively and specifically diagnose Ewing sarcoma micro-metastases inspired a growing interest in targeted immunotherapeutics. She has subsequent training in cancer immunology, including but not limited to antibody humanization, characterization, and engineering, has generated the skills necessary to pursue novel immunotherapeutics for pediatric patients. In concert with preclinical training, Dr. O’Neill has focused on developing clinical solid tumor expertise, recognizing my career goals of becoming a leader in the care of solid tumor patients with a focus on translational research and innovation. She leads the Dana-Farber/Boston Children’s pediatric Liver Tumor Center, working closely with surgeons, interventional radiologists, and preclinical researchers to bring innovative care to patients with all types of primary liver tumors. She is the Chair of the Children's Oncology Group Liver Tumor Committee and work closely with international colleagues affiliated with the Paediatric Hepatic International Tumor Trial (PHITT) and SIOP Liver Tumor Working Group. She has a unique split between patient care and research has allowed an opportunity to develop and refine skills in teaching medical students, residents and fellows; training laboratory technicians and post-doctoral fellows; and counseling trainees regarding the intricacies relevant to a career in translational research.